Deoxidation tower structure and technical operation

Replacement of zinc powder, deoxidizing effect is a very important control index. At present, vacuum deoxidation towers are commonly used in the industry. The following figure is a volume of 0. 5 ~ 1 .0 cubic meters Schematic diagram of the structure of a cylindrical deoxidizer. Its exhaust pipe is connected to a vacuum pump to create a vacuum. After the noble liquid enters the tower from the inlet 1 , it is splashed into dots by the wooden strip 2 to increase the surface area for degassing. The deliqueurized noble liquid flows out from the tower discharge port 6 , so that the deoxidized noble liquid maintains a certain level in the tower, and the buoy 4 , the counterweight 5 and the butterfly valve 7 can accomplish this task. Column vacuum up to 600 to 650 mmHg, expensive liquid oxygen after deoxidation of 0.6 to 0.8 mg / L.

Upadacitinib Intermediates

Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by synovial inflammation and hyperplasia, autoantibody production, cartilage damage and bone destruction, leading to co-morbidities. Despite a variety of therapeutic agents available for treatment, up to 40% of the patients do not respond to current therapies, including biological therapies. The etiology of the disease is mostly unknown; however, the role of JAK as a driver of immune-mediated conditions was discovered, leading to the use of JAK as therapeutic targets for rheumatoid arthritis. To reduce dose-related toxicity (as seen with some pan-JAK inhibitors) without significantly affecting efficacy, more selective JAK1 inhibitors, upadacitinib and [filgotinib], were developed. The FDA approved Upadacitinib in August 2019 for the treatment of adults with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate. In December 2019, it was additionally approved by the European Commission for the same indication in patients with inadequate response or intolerance to one or more DMARDs and can be used as monotherapy or in combination with methotrexate. Upadacitinib is marketed under the brand name RINVOQâ„¢ for oral administration. It is currently being investigated in several clinical trials assessing its therapeutic effectiveness in other inflammatory diseases, such as psoriatic arthritis, ankylosing spondylitis, ulcerative colitis, and atopic dermatitis.

Upadacitinib Cas 1201187-44-1,Upadacitinib Cas 1428243-26-8,Upadacitinib Intermediate Cas 1201187-44-1,Upadacitinib Intermediate Cas 1428243-26-8

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